منابع مشابه
Dosage compensation in Drosophila.
Dosage compensation in Drosophila increases the transcription of genes on the single X chromosome in males to equal that of both X chromosomes in females. Site-specific histone acetylation by the male-specific lethal (MSL) complex is thought to play a fundamental role in the increased transcriptional output of the male X. Nucleation and sequence-independent spreading of the complex to active ge...
متن کاملTargeting Determinants of Dosage Compensation in Drosophila
The dosage compensation complex (DCC) in Drosophila melanogaster is responsible for up-regulating transcription from the single male X chromosome to equal the transcription from the two X chromosomes in females. Visualization of the DCC, a large ribonucleoprotein complex, on male larval polytene chromosomes reveals that the complex binds selectively to many interbands on the X chromosome. The t...
متن کاملStudy of dosage compensation in Drosophila.
Using a sensitive RT-QPCR assay, we analyzed the regulatory effects of sex and different dosage compensation mutations in Drosophila. To validate the assay, we showed that regulation for several genes indeed varied with the number of functional copies of that gene. We then confirmed that dosage compensation occurred for most genes we examined in male and female flies. Finally, we examined the e...
متن کاملX chromosome dosage compensation in Drosophila.
a colon length of 15,000 crypts. The mean width of the observed adenomas was seven crypts (although this figure is an overestimate of x, because it was observed after any collisions had occurred, which presumably had the effect of increasing x). We analyzed the model assuming different values of n and determining whether these values can account for two observations: (i) the final figure of 300...
متن کاملDosage compensation of serine-4 transfer RNA in Drosophila melanogaster.
A dosage series of the X chromosome site for serine-4 transfer RNA consisting of one of three copies in females and one to two in males was constructed to test whether transfer RNA expression is governed by dosage compensation. A dosage effect on the level of the serine-4 isoacceptor was observed in both females and males when the structural locus was varied. However, in males, each dose had a ...
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ژورنال
عنوان ژورنال: Fly
سال: 2011
ISSN: 1933-6934,1933-6942
DOI: 10.4161/fly.5.2.14934